Saumik Biswas

  • Program Graduate

Contact Info:

  • WIRB, 7th Floor

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Education

PhD, Pathology and Laboratory Medicine, Western University
BSc (Honours), Medical Sciences, Brock University

Biography

Saumik pursued his doctoral studies in Pathology and Laboratory Medicine at Western University. Saumik’s research primarily focused on elucidating the interplay between epigenetic mechanisms and disease pathogenesis in diabetic complications. During the course of his PhD, Saumik has published over 12 manuscripts (including 2 book chapters), and has acquired over $60,000 in scholarships and awards (i.e. Nellie Farthing Fellowship in Medical Sciences). Saumik was also awarded the ‘Mitacs Globalink Research Award’ in 2019, where he was able to partake in a research internship at the University of Hong Kong and work alongside a renowned diabetes scientist/ biotechnology entrepreneur on a novel research project for several months. Saumik plans to be actively involved in translational research, where he too can improve the quality of lives of others through medical innovation.

Publications

Biswas S, Chakrabarti S. “Pathogenetic Mechanisms in Diabetic Retinopathy: From Molecules to Cells to Tissues”. In: Kartha CC, Ramachandran S, Pillai RM, eds. Mechanisms of Vascular Defects in Diabetes Mellitus. Cham: Springer International Publishing; 2017:209-247. doi:10.1007/978-3-319-60324-7_9.

Gordon A, Biswas S, Feng B, Chen S, Chakrabarti S.“MALAT1: A Regulator of Inflammatory Cytokines in Diabetic Complications”. Endocrinology, Diabetes & Metabolism; 2018. doi: 10.1002/edm2.10.

Biswas S, Thomas AA, Chen S, Aref-Eshghi E, Feng B, Gonder J, Sadikovic B, Chakrabarti S. “MALAT1: An Epigenetic Regulator of Inflammation in Diabetic Retinopathy”. Scientific Reports: 2018;8(1). doi:10.1038/s41598-018-24907-w.

Biswas S, Feng B, Thomas AA, Chen S, Aref-Eshghi E, Sadikovic B, Chakrabarti S. “Endothelin-1 regulation is entangled in a complex web of epigenetic mechanisms in diabetes”. Physiological Research: 2018;67(Supplementum 1): S115-S125.

Biswas S, Thomas AA, Chakrabarti S.LncRNAs: Proverbial Genomic “Junk” or Key Epigenetic Regulators During Cardiac Fibrosis in Diabetes?”. Frontiers in Cardiovascular Medicine. 2018; 5:28. doi:10.3389/fcvm.2018.00028.

Thomas AA,Biswas S, Feng B, Chen S, Gonder J, Chakrabarti S. lncRNA H19 prevents endothelial–mesenchymal transition in diabetic retinopathy. Diabetologia. January 2019. doi:10.1007/s00125-018-4797-6.

Biswas S, Chakrabarti S. Increased Extracellular Matrix Protein Production in Chronic Diabetic Complications: Implications of Non-Coding RNAs.Non-Coding RNA. 2019;5(1). doi:10.3390/ncrna5010030.

Biswas S, Sarabusky M, Chakrabarti S. Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network. J. Clin. Med. 2019; 8, 1033. https://doi.org/10.3390/jcm8071033.

Biswas S, Chen S, Liang G, Feng B, Cai L, Khan ZA, Chakrabarti S. “Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes”.Frontiers in Endocrinology, 10, 887. https://doi.org/10.3389/fendo.2019.00887.

Liu J, Chen S, Biswas S, Nagrani N, Chu Y, Chakrabarti S. “Glucose-induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs”. Physiological Reports. 2020; 8(3). p.e14331.

Biswas, S., & Chakrabarti, S. (2020). The Multifaceted Roles of LncRNAs in Diabetic Complications: A Promising Yet Perplexing Paradigm. In S. Jurga & J. Barciszewski (Eds.), The Chemical Biology of Long Noncoding RNAs (pp. 491–521). Cham: Springer International Publishing. http://doi.org/10.1007/978-3-030-44743-4_19

Aref-Eshghi E, Biswas S, Chen C, Sadikovic B, Chakrabarti S. (2020). Glucose-induced duration-dependent genome-wide DNA methylation changes in human endothelial cells. American Journal of Physiology-Cell Physiology. http://doi.org/10.1152/ajpcell.00011.2020

Zheng H, Baranova K, Song J, Yan L, Biswas S, Chakrabarti S, Zhang Q. “Overexpression of Long Noncoding RNA HOTAIR Is a Unique Epigenetic Characteristic of Myxopapillary Ependymoma”. Journal of Neuropathology & Experimental Neurology. 2020; nlaa103. https://doi.org/10.1093/jnen/nlaa103

Biswas, S., Feng, B., Chen, S., Liu, J., Aref-Eshghi, E., Gonder, J., Ngo, V., Sadikovic, B., & Chakrabarti, S. (2021). The Long Non-Coding RNA HOTAIR Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy. Investigative ophthalmology & visual science, 62(3), 20. https://doi.org/10.1167/iovs.62.3.20